NCIt definition : A replication-incompetent, pathotropic, tumor matrix (collagen)-targeted, retroviral
vector encoding an N-terminal deletion mutant form of the cyclin G1 gene with potential
antineoplastic activity. Under the control of a hybrid long-terminal repeat/cytomegalovirus
(CMV) promoter, retrovector encoding mutant anti-cyclin G expresses the mutant cyclin
G1 construct, resulting in disruption of tumor cell cyclin G1 activity and decreased
cellular proliferation and angiogenesis. This agent preferentially targets collagen
of the tumor matrix because of the incorporation of the collagen-binding domain of
von Willebrand factor (vWF) on the retrovector surface. Exploiting the collagen-targeting
mechanism of vWF permits delivery of the retrovector to tumor sites where angiogenesis
and collagen matrix exposure occur.;