" /> Ropidoxuridine - CISMeF





Preferred Label : Ropidoxuridine;

NCIt synonyms : IPdR; 5-Iodo-2-Pyrimidinone-2-Deoxyribose; 5-Iodo-2-pyrimidinone-2'-deoxyribose; 5-Iodo-2-pyrimidinone 2' deoxyribonucleoside; 2(1H)-Pyrimidinone, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-iodo-;

NCIt definition : An orally available 5-substituted 2-pyrimidinone-2'-deoxyribonucleoside analogue and prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine, with radiosensitizing activity. Upon oral administration, ropidoxuridine (IPdR) is efficiently converted to idoxuridine (IUdR) by a hepatic aldehyde oxidase. In turn, IUdR is incorporated into DNA during replication, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. Compared to IUdR, ropidoxuridine is associated with a lower toxicity profile and improved anti-tumor activity.;

UNII : 3HX21A3SQF;

InChIKey : XIJXHOVKJAXCGJ-XLPZGREQSA-N;

CAS number : 93265-81-7;

Chemical formula : C9H11IN2O4;

NSC code : 726188;

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30/05/2025


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