NCIt definition : A general term that refers to a TNM finding of a primary tumor with direct invasion
of adjacent structures. The definition of T4d TNM finding depends on the specific
type of cancer that it refers to; for example, for breast cancer it refers to a primary
tumor that meets the clinical-pathologic criteria of inflammatory carcinoma; for ocular
adnexal lymphoma it refers to a primary tumor with intracranial spread; for carcinoma
of the conjunctiva it refers to a primary tumor that invades the brain.;