NCIt definition : A general term that refers to a TNM finding of a primary tumor with direct invasion
of adjacent structures. The definition of T4c TNM finding depends on the specific
type of cancer that it refers to; for example, for breast cancer it refers to a primary
tumor that extends to the chest wall, not including the pectoralis muscle, and with
edema (including peau d'orange) or ulceration of the skin of the breast or satellite
skin nodules confined to the same breast; for ocular adnexal lymphoma it refers to
a primary tumor that Involves the maxillofacial, ethmoidal, and/or frontal sinuses;
for carcinoma of the conjunctiva it refers to a primary tumor that invades adjacent
paranasal sinuses.;
Currated CISMeF NLP mapping