NCIt definition : A general term that refers to a TNM finding of a primary tumor with direct invasion
of adjacent structures. The definition of T4b TNM finding depends on the specific
type of cancer that it refers to; for example, for bladder cancer it refers to a primary
tumor that invades the pelvic wall and abdominal wall; for gastric cancer it refers
to a primary tumor that invades adjacent structures; for colorectal cancer it refers
to a primary tumor with direct invasion or adherence to other organs or structures.;