NCIt definition : A TNM finding indicating the spread of cancer to distant anatomic sites. The definition
of M1c TNM finding depends on the specific type of cancer that it refers to; for example,
for prostate cancer it refers to metastasis to anatomic site(s) other than bone, with
or without bone disease; for retinoblastoma it refers to central nervous system metastasis;
for melanoma of the uvea it refers to distant metastasis, with the largest diameter
of the largest metastasis measuring 8.0 cm or more.;