Preferred Label : Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7.1-B7.2 Vaccine;
NCIt synonyms : Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7 1-B7 2 Vaccine;
NCIt definition : A cancer vaccine consisting of an inactivated recombinant vaccinia virus encoding
epitope peptides derived from melanoma-related HLA-A2-restricted tumor-associated
antigens (TAAs), including Melan-A(27-35), gp100(280-288) and tyrosinase(1-9), and
two co-stimulatory B7 proteins, B7.1 (CD80) and B7.2 (CD86). Upon administration,
recombinant vaccinia-multiepitope melanoma peptides-B7.1-B7.2 vaccine may stimulate
a cytotoxic T-lymphocyte response against melanoma cells that express TAAs which share
epitopes with the epitope peptides expressed by the vaccine viral vector, resulting
in tumor cell lysis; vaccine viral vector-expressed co-stimulatory proteins B7.1 and
B7.2 may enhance the cytotoxic T-lymphocyte immune response to the TAAs.;
Origin ID : C48638;
UMLS CUI : C1709860;
Semantic type(s)
- concept_is_in_subset
