gp100:614-622 Peptide

Preferred Label : gp100:614-622 Peptide;

NCIt synonyms : gp100 614-622 Peptide;

NCIt definition : A synthetic peptide consisting of amino acid residues 614 through 622 of the melanoma-melanocyte antigen glycoprotein 100 (gp100). Vaccination with gp100:614-622 peptide may stimulate a cytotoxic T-cell immune response against tumor cells that express this antigen, resulting in decreased tumor growth and cell lysis. gp100 antigen is a self-antigen expressed by melanocytes, pigmented retinal cells and most melanoma lesions and recognized via class I and II HLA-restricted mechanisms.;

NSC code : 732518;

Details

Origin ID

C48631;

UMLS CUI

C1711419;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_affects_abnormal_cell
- Melanoma Cell [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Immunopotentiation [NCIt concept]
- T-Cell Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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