Preferred Label : Yttrium Y-90 Tacatuzumab Tetraxetan;
NCIt synonyms : Yttrium Y 90 DOTA Monoclonal Antibody HuAFP31; Y-90 hAFP-31; Yttrium Y 90 Tacatuzumab Tetraxetan; Yttrium (90Y) Tacatuzumab Tetraxetan;
NCIt definition : A radioimmunoconjugate comprised of the humanized monoclonal antibody tacatuzumab,
directed against alpha fetoprotein, that is conjugated to the chelating agent tetraxetan
and radiolabeled with the beta-emitting radioisotope Yttrium Y 90. Yttrium Y 90 tacatuzumab
tetraxetan binds to tumor cells expressing alpha fetoprotein, thereby selectively
delivering a cytotoxic dose of beta radiation.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of liver cancer. HuAFP31 is
a monoclonal antibody that can bind to tumor cells that make a protein called alpha
fetoprotein (AFP). It is linked to a radioactive substance called yttrium Y 90, which
may help kill the cancer cells. Yttrium Y 90 DOTA monoclonal antibody HuAFP31 is a
type of radioimmunoconjugate.;
UNII : GJ2416WK6Y;
CAS number : 476413-07-7;
Drug name : AFP-Cide;
Chemical formula : C16H25N5O7.Y;
Codes from synonyms : CDR0000560639;
Origin ID : C48428;
UMLS CUI : C1541525;
Semantic type(s)
- concept_is_in_subset
