Larotaxel - CISMeF

Preferred Label : Larotaxel;

NCIt related terms : RPR 109881A; XRP9881;

NCIt definition : A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates the blood brain barrier.;

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of breast cancer. It belongs to the family of drugs called taxane derivatives.;

UNII : TWQ8K8A81Y;

InChIKey : DXOJIXGRFSHVKA-BZVZGCBYSA-N;

CAS number : 156294-36-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 156294-36-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RPR 109881A; RPR-109881; Taxoid-109881;

Chemical formula : C45H53NO14;

Codes from synonyms : CDR0000430877; CDR0000045512;

Details

Origin ID

C48427;

UMLS CUI

C2603883;

Currated CISMeF NLP mapping
- larotaxel [MeSH concept]
- larotaxel [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- larotaxel [MeSH Supplementary Concept]
- larotaxel [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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