NCIt definition : A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic
activities. Larotaxel binds to tubulin, promoting microtubule assembly and stabilization
and preventing microtubule depolymerization, thereby inhibiting cell proliferation.
As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms,
this agent may be useful for treating multi-drug resistant tumors. Larotaxel penetrates
the blood brain barrier.;
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of breast cancer. It
belongs to the family of drugs called taxane derivatives.;
UNII : TWQ8K8A81Y;
InChIKey : DXOJIXGRFSHVKA-BZVZGCBYSA-N;
CAS number : 156294-36-9;
Molecule name : RPR 109881A; RPR-109881; Taxoid-109881;
Chemical formula : C45H53NO14;
Codes from synonyms : CDR0000430877; CDR0000045512;