Taxane Analogue TPI 287

Preferred Label : Taxane Analogue TPI 287;

NCIt synonyms : TPI 287;

NCIt definition : A synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.;

CAS number : 849213-15-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 849213-15-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : TPI 287;

Details

Origin ID

C48424;

UMLS CUI

C1710314;

Automatic exact mappings (from CISMeF team)
- TPI-287 [MeSH concept]
- TPI-287 [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TPI-287 [MeSH Supplementary Concept]
- TPI-287 [MeSH concept]
chemical_or_drug_has_mechanism_of_action
- Microtubule Process [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tubulin [NCIt concept]

Keyword's position in hierarchy(ies) :

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