NCIt definition : A biodegradable poly(ethylene glycol)-poly(D,L-lactide) copolymer micelle nanoparticle-entrapped
formulation of paclitaxel with antineoplastic activity. Paclitaxel promotes microtubule
assembly and prevents depolymerization, thus interfering with normal mitosis. The
copolymer residue increases the water-solubility of paclitaxel and allows delivery
of higher doses than those achievable with paclitaxel alone.;
Alternative definition : NCI-GLOSS: A form of the anticancer drug paclitaxel used to treat breast cancer, ovarian
cancer, and AIDS-related Kaposi sarcoma. It is also used with another drug to treat
non-small cell lung cancer. Paclitaxel is mixed with very tiny particles of a substance
that makes it easier to dissolve in water. This allows higher doses of paclitaxel
to be given. It is a type of antimitotic agent.;
Manual NTBT mappings (CISMeF)