Preferred Label : Opioid Growth Factor;
NCIt synonyms : OGF;
CISMeF acronym : OGF;
NCIt definition : An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities.
Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some
tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis.
(NCI05);
Alternative definition : NCI-GLOSS: A substance that relieves pain and is being studied in the treatment of
some types of cancer. Opioid growth factors bind to cells in the body, including tumor
cells, which have opioid growth factor receptors on the surface. This may help stop
the growth of the tumor cells. It may also prevent the growth of blood vessels that
tumors need to grow. An opioid growth factor is a type of biological response modifier
and a type of antiangiogenesis agent.;
Codes from synonyms : CDR0000439442; CDR0000439441;
Origin ID : C48413;
UMLS CUI : C1541553;
Semantic type(s)
- concept_is_in_subset
