Preferred Label : Cretostimogene Grenadenorepvec;
NCIt synonyms : Oncolytic Adenovirus Encoding GM-CSF;
NCIt definition : A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage
colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration,
cretostimogene grenadenorepvec selectively infects and replicates in tumor cells,
which may result in tumor cells lysis. Synergistically, GM-CSF expressed by the oncolytic
adenovirus may promote a cytotoxic T cell response against tumor cells harboring the
oncolytic adenovirus, resulting in an immune-mediated tumor cell death.;
UNII : THP9ML4NTZ;
CAS number : 2414312-87-9;
Molecule name : CG 0070; CG-0070;
Origin ID : C48412;
UMLS CUI : C5708868;
Semantic type(s)
- concept_is_in_subset
