Preferred Label : Monoclonal Antibody RAV12;
NCIt synonyms : anti-RAAG12 MOAB;
NCIt related terms : RAV12;
NCIt definition : A chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate
epitope (glycotope) expressed on various human carcinomas with potential antineoplastic
activity. Following binding, monoclonal antibody RAV12 disrupts sodium channels of
tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss
of membrane integrity, and cell death. (NCI05);
Alternative definition : NCI-GLOSS: A monoclonal antibody that is being studied in the treatment of some types
of cancer. Monoclonal antibodies are made in the laboratory and can locate and bind
to cancer cells. It binds to a carbohydrate (sugar) molecule that is found on gastric,
colon, pancreatic, prostate, ovarian, breast, and kidney cancer cells.;
Codes from synonyms : CDR0000423252;
Origin ID : C48409;
UMLS CUI : C1541489;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
