Preferred Label : HLA-A2, A3-Restricted FGF-5 Peptides/Montanide ISA-51 Vaccine;
NCIt synonyms : HLA-A2-FGF-5; HLA-A2 A3-Restricted FGF-5 Peptides Montanide ISA-51 Vaccine;
NCIt definition : A peptide vaccine comprised of synthetic HLA-A2- and HLA-A3-binding peptides, derived
from amino acid sequences of fibroblast growth factor-5 (FGF-5), combined with the
adjuvant Montanide ISA-51 with potential antineoplastic activity. HLA-A2, A3-restricted
FGF-5 peptides contain motifs recognized by the MHC class I molecules HLA-A2 and HLA-A3
and may stimulate a cytotoxic T-cell response against tumor cells that overexpress
FGF-5. Montanide ISA-51, a stabilized water-in-oil emulsion adjuvant containing mineral
oil with mannide oleate added as a surfactant, non-specifically stimulates cell-mediated
immune responses to antigens.;
Origin ID : C48394;
UMLS CUI : C1541599;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
