Preferred Label : HLA-A1, A2, B35-Restricted Survivin Peptides/Montanide ISA-51 Vaccine;
NCIt synonyms : Survivin Peptide Vaccine; HLA-A1 A2 B35-Restricted Survivin Peptides Montanide ISA-51 Vaccine;
NCIt definition : A peptide vaccine comprised of synthetic HLA-A1, -A2 and -B35 restricted survivin
epitopes combined with the adjuvant Montanide ISA-51 with potential antineoplastic
activity. Upon administration, HLA-A1, A2, B35-restricted survivin peptides/Montanide
ISA-51 vaccine may stimulate a cytotoxic T cell response against tumor cells that
overexpress survivin, resulting in tumor cell lysis. Montanide ISA-51, also known
as incomplete Freund's adjuvant or IFA, is a stabilized water-in-oil emulsion adjuvant
containing mineral oil with mannide oleate added as a surfactant that non-specifically
stimulates cell-mediated immune responses to antigens.;
Origin ID : C48393;
UMLS CUI : C1708275;
Semantic type(s)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
