" /> Bardoxolone - CISMeF





Preferred Label : Bardoxolone;

NCIt synonyms : Oleana-1,9(11)-dien-28-oic acid, 2-cyano-3,12-dioxo-; 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid; CDDO;

NCIt related terms : 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid;

NCIt definition : A synthetic triterpenoid compound with potential antineoplastic and anti-inflammatory activities. Bardoxolone blocks the synthesis of inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2), two enzymes involved in inflammation and carcinogenesis. This agent also inhibits the interleukin-1 (IL-1)-induced expression of the pro-inflammatory proteins matrix metalloproteinase-1 (MMP-1) and matrix metalloproteinase-13 (MMP-13) and the expression of Bcl-3; Bcl-3 is an IL-1-responsive gene that preferentially contributes to MMP-1 gene expression.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. CDDO may block enzymes involved in inflammation and cancer growth. It is a type of antineoplastic plant product.;

UNII : 7HT68L8941;

InChIKey : TXGZJQLMVSIZEI-UQMAOPSPSA-N;

CAS number : 218600-44-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 218600-44-3 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RTA 401;

Chemical formula : C31H41NO4;

NSC code : 711193;

Codes from synonyms : 31757; CDR0000518302;

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12/05/2024


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