Preferred Label : Allogeneic GM-CSF-Secreting Breast Cancer Vaccine;
NCIt synonyms : GM-CSF BREAST VAC;
NCIt related terms : GM-CSF-secreting breast tumor vaccine;
NCIt definition : An allogenic vaccine consisting of irradiated breast cancer cells transfected with
the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene. Upon vaccination,
the genetically modified cells secrete GM-CSF, thereby potentiating a tumor-specific
T cell response against breast cancer cell-asociated antigens.;
Alternative definition : NCI-GLOSS: A vaccine that is being studied as a way to help the body's immune system
kill breast cancer cells. To make the vaccine, the GM-CSF gene is put into breast
cancer cells in the laboratory. The cells are then treated with radiation to stop
them from growing and injected into the same or a different patient. The GM-CSF protein
made by the changed breast cancer cells may help the immune system kill breast cancer
cells in the body.;
Codes from synonyms : CDR0000661957;
Origin ID : C48371;
UMLS CUI : C1541366;
Semantic type(s)
- concept_is_in_subset
