Multikinase Inhibitor AEE788

Preferred Label : Multikinase Inhibitor AEE788;

NCIt related terms : AEE 788; AEE-788; AEE788;

NCIt definition : An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05);

Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs to the families of drugs called protein tyrosine kinase inhibitors and angiogenesis inhibitors.;

UNII : F9JLR95I3I;

CAS number : 497839-62-0;

Molecule name : AEE-788;

Codes from synonyms : CDR0000386196; 50710;

Details

Origin ID

C48369;

UMLS CUI

C1506057;

Currated CISMeF NLP mapping
- AEE 788 [MeSH Supplementary Concept]
- AEE 788 [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- AEE 788 [MeSH concept]
- AEE 788 [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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