NCIt definition : An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits
phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR),
human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor
receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation,
and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05);
Alternative definition : NCI-GLOSS: A substance that is being studied in the treatment of cancer. It belongs
to the families of drugs called protein tyrosine kinase inhibitors and angiogenesis
inhibitors.;
UNII : F9JLR95I3I;
CAS number : 497839-62-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 497839-62-0
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