Preferred Label : Primary Hyperparathyroidism;
NCIt definition : Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid
hormone. It is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid
carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and
hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting,
constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney
stones.;
Alternative definition : NICHD: Hyperparathyroidism due to a condition originating within the parathyroid glands,
resulting in hypercalcemia due to increased release of calcium and phosphate from
bone matrix, increased renal calcium reabsorption, and increased renal production
of 1,25-dihydroxyvitamin D, which increases intestinal absorption of calcium. Primary
hyperparathyroidism is also associated with hypophosphatemia as a result of phosphaturia.
Clinical features include weakness, fatigue, nausea, vomiting, constipation, depression,
and, if chronic, bone pain, osteoporosis, cystic bone lesions, and kidney stones.;
Origin ID : C48280;
UMLS CUI : C0221002;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- Has associated anatomic sites
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- disease_has_associated_disease
- disease_has_primary_anatomic_site
- may_be_associated_disease_of_disease
