NCIt synonyms : 131I-TM-601; 131I-Chlorotoxin; 131I-TM601; I 131 TM-601;
NCIt definition : An iodine 131 (I 131) radioconjugate of the synthetic chlorotoxin (CTX) TM-601 with
potential antiangiogenic and antineoplastic activities. CTX is a 36 amino acid neurotoxin
found in the venom of the giant yellow scorpion Leiurus quinquestriatus that preferentially
binds malignant cells of neuroectodermal origin. The recombinant version of this peptide,
TM-601, is expressed in and purified from E. coli and then covalently linked to I
131 to produce 131I-TM-601. 131I-TM-601 binds to tumor cells of neuroectodermal origin
and is internalized; administered once, it may be used as a radioimaging agent; repeated
administration may result in a tumor-specific, cumulative radiocytotoxic dose of I
131. In addition, TM-601 alone, similar to native CTX, may inhibit angiogenesis due
to its ability to bind to and inhibit matrix metalloproteinase 2 (MMP-2), an endopeptidase
involved in tissue remodeling processes such as angiogenesis.;