NCIt definition : The instability of chromosomes is attributed to the continuous formation of novel
chromosome mutations. These mutations form at an elevated rate in comparison to the
normal cell population. The increased frequency of structural chromosome aberrations
can be caused by an abnormally high incidence of DNA double-strand breaks and translocations.
Screening for chromosomal breakage and rearrangement is used as a diagnostic tool
in Fanconi anemia.;
Currated CISMeF NLP mapping