NCIt definition : The hydrochloride salt form of chlorpromazine, a phenothiazine and traditional antipsychotic
agent with anti-emetic activity. Chlorpromazine hydrochloride exerts its antipsychotic
effect by blocking postsynaptic dopamine receptors in cortical and limbic areas of
the brain, thereby preventing the excess of dopamine in the brain. This leads to a
reduction in psychotic symptoms, such as hallucinations and delusions. Chlorpromazine
hydrochloride appears to exert its anti-emetic activity by blocking the dopamine receptors
in the chemical trigger zone (CTZ) in the brain, thereby relieving nausea and vomiting.;