NCIt definition : The sodium salt form of cefamandole, a beta-lactam, second-generation cephalosporin
antibiotic with bactericidal activity. Cefamandole binds to and inactivates penicillin-binding
proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation
of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial
cell wall strength and rigidity. This results in the weakening of the bacterial cell
wall and causes cell lysis.;