Preferred Label : Cefamandole Nafate;
NCIt synonyms : Cefam; O-Formylcefamandole Sodium;
NCIt definition : The sodium salt form of cefamandole formyl ester. Cefamandole nafate is a pro-drug
that is hydrolyzed by plasma esterases to produce cefamandole, a semi-synthetic beta-lactam,
second-generation cephalosporin antibiotic with bactericidal activity. Cefamandole
binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane
of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage
of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This
results in the weakening of the bacterial cell wall and causes cell lysis.;
UNII : 8HDO7941DO;
InChIKey : ICZOIXFFVKYXOM-YCLOEFEOSA-M;
CAS number : 42540-40-9;
Drug name : Mandol; Cedol; Mandolsan; Bergacef;
Molecule name : Lilly 106223;
Chemical formula : C19H17N6O6S2.Na;
NSC code : 299588;
ChEBI ID : CHEBI:3481;
Origin ID : C47966;
UMLS CUI : C0054995;
Semantic type(s)
- concept_is_in_subset
