Zonisamide - CISMeF

Preferred Label : Zonisamide;

NCIt synonyms : Excegram; 1,2-Benzisoxazole-3-methanesulfonamide;

NCIt definition : A sulfonamide derivative with an anticonvulsant property. The exact mechanism of action remains to be elucidated. Zonisamide appears to block sodium and calcium channels, thereby stabilizing neuronal membranes and suppressing neuronal hyper-synchronization. Although zonisamide shows affinity for the gamma-aminobutyric acid (GABA)/benzodiazepine receptor ionophore complex, it does not potentiate the synaptic activity of GABA. In addition, this agent also facilitates both dopaminergic and serotonergic neurotransmission.;

UNII : 459384H98V;

InChIKey : UBQNRHZMVUUOMG-UHFFFAOYSA-N;

CAS number : 68291-97-4;

Drug name : Zonegran;

Chemical formula : C8H8N2O3S;

ChEBI ID : CHEBI:10127;

Details

Origin ID

C47790;

UMLS CUI

C0078844;

Automatic exact mappings (from CISMeF team)
- zonisamide [medical devices type]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing zonisamide (medicinal product) [SNOMED CT concept]
- Zonisamide [MeSH Descriptor]
- Zonisamide [LOINC component]
- Zonisamide (substance) [SNOMED CT concept]
- zonisamide [ATC Code]
- zonisamide [Substance BNPC]
- zonisamide [MeSH concept]
Validated automatic mappings to BTNT
- zonisamide [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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