Preferred Label : Zafirlukast;
NCIt synonyms : Carbamic Acid,(3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-,
Cyclopentyl Ester; Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate;
NCIt related terms : Accolate;
NCIt definition : A tolyl compound and leukotriene receptor antagonist (LTRA), with anti-asthmatic and
potential capsular contracture-preventing activities. Upon administration, zafirlukast
selectively and competitively binds to and blocks the cysteinyl leukotriene 1 receptor
(CYSLTR1), thereby preventing the potent pro-inflammatory mediators leukotriene C4,
D4 and E4 from binding. This prevents leukotriene-mediated actions, including enhanced
migration of eosinophils and neutrophils, increased adhesion of leukocytes, increased
monocyte and neutrophil aggregation, increased airway edema, inflammation, capillary
permeability and bronchoconstriction. In addition, zafirlukast may decrease collagen
deposition, fibrosis, and capsular thickness after implantation, thereby preventing
scar tissue.;
Alternative definition : NCI-GLOSS: A drug used to prevent and treat symptoms of asthma. It blocks substances
that cause inflammation in the lungs. It is a type of antiasthmatic agent and a leukotriene
receptor antagonist.;
UNII : XZ629S5L50;
InChIKey : YEEZWCHGZNKEEK-UHFFFAOYSA-N;
CAS number : 107753-78-6;
Drug name : Accolate;
Chemical formula : C31H33N3O6S;
ChEBI ID : CHEBI:10100;
Codes from synonyms : CDR0000631063; CDR0000631064; 20039;
Origin ID : C47785;
UMLS CUI : C0378466;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
