NCIt definition : An orally active nonpeptide triazole-derived antagonist of angiotensin (AT) II with
antihypertensive properties. Valsartan selectively and competitively blocks the binding
of angiotensin II to the AT1 subtype receptor in vascular smooth muscle and the adrenal
gland, preventing AT II-mediated vasoconstriction, aldosterone synthesis and secretion,
and renal reabsorption of sodium, and resulting in vasodilation, increased excretion
of sodium and water, a reduction in plasma volume, and a reduction in blood pressure.;