Trihexyphenidyl Hydrochloride

Preferred Label : Trihexyphenidyl Hydrochloride;

NCIt synonyms : Cyclodol; 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-, Hydrochloride;

NCIt definition : The hydrochloride salt form of trihexyphenidyl, a synthetic, substituted piperidine with parasympatholytic activity used mostly in Parkinson's disease. Trihexyphenidyl hydrochloride antagonizes activities of acetylcholine via muscarinic receptors. This balances the cholinergic and dopaminergic activity in the basal ganglia leading to an improvement of classic Parkinson symptoms such as rigidity and tremor. In addition, trihexyphenidyl hydrochloride exerts a direct antispasmodic effect on smooth muscle.;

UNII : AO61G82577;

InChIKey : QDWJJTJNXAKQKD-UHFFFAOYSA-N;

CAS number : 52-49-3;

Drug name : Artane;

Chemical formula : C20H31NO.HCl;

Details

Origin ID

C47771;

UMLS CUI

C0003830;

Automatic exact mappings (from CISMeF team)
- trihexyphenidyl [MeSH Descriptor]
Currated CISMeF NLP mapping
- Trihexyphenidyl Hydrochloride [MeSH concept]
- Trihexyphenidyl hydrochloride [Substance BNPC]
- Trihexyphenidyl hydrochloride [SMS substance]
- Trihexyphenidyl hydrochloride (substance) [SNOMED CT concept]
- trihexyphenidyl hydrochloride [SNOMED Notion]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
Validated automatic mappings to NTBT
- trihexyphenidyl [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
has_free_acid_or_base_form
- Trihexyphenidyl [NCIt concept]
is_salt_form_of
- Trihexyphenidyl [NCIt concept]

Keyword's position in hierarchy(ies) :

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