" /> Trazodone Hydrochloride - CISMeF





Preferred Label : Trazodone Hydrochloride;

NCIt synonyms : 2-(3-(4-(3-Chlorophenyl)piperazin-1-y)propyl)-1,2,4-triazolo(4,3-a)pyridine-3(2H)-one Hydrochloride; 1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Monohydrochloride;

NCIt definition : The hydrochloride salt form of trazodone, a synthetic triazolopyridine derivative with antidepressant and sedative properties. Based on studies from animal models, trazodone selectively inhibits the re-uptake of serotonin by synaptosomes in the brain, thereby increasing serotonin levels in the synaptic cleft and potentiating serotonin activity. Trazodone is not a monoamine oxidase inhibitor and, unlike amphetamine-type drugs, does not stimulate the central nervous system. The sedative effect of trazodone is likely via alpha-adrenergic and mild histamine H1 blocking actions.;

UNII : 6E8ZO8LRNM;

InChIKey : OHHDIOKRWWOXMT-UHFFFAOYSA-N;

CAS number : 25332-39-2;

Drug name : Trialodine; Desyrel;

Chemical formula : C19H22ClN5O.HCl;

NSC code : 292811;

ChEBI ID : CHEBI:9655;

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08/05/2025


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