Preferred Label : Tolnaftate;
NCIt synonyms : Tinactin; Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester; Focusan; Tolsanil; Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester;
NCIt definition : A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate
is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3-
epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads
to the accumulation of squalene and a deficiency in ergosterol, an essential component
of fungal cell walls, thereby increasing membrane permeability, disrupting cellular
organization and causing cell death. In addition, this agent may also distort the
hyphae and stunts mycelial growth in susceptible fungi.;
UNII : 06KB629TKV;
InChIKey : FUSNMLFNXJSCDI-UHFFFAOYSA-N;
CAS number : 2398-96-1;
Drug name : Absorbine; Genaspor; Desenex; Aftate;
Molecule name : NP 27;
Chemical formula : C19H17NOS;
NSC code : 233648;
Origin ID : C47763;
UMLS CUI : C0040379;
Automatic exact mappings (from CISMeF team)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
