Preferred Label : Tizanidine Hydrochloride;
NCIt synonyms : 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, Monohydrochloride; 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Hydrochloride;
NCIt definition : The hydrochloride salt form of tizanidine, an imidazoline derivative structurally
similar to clonidine and an adrenergic agonist with muscle relaxant property. Tizanidine
stimulates alpha-2 adrenergic receptors in the central nervous system, thereby inhibiting
presynaptic release of norepinephrine and increasing the inhibitory effect on alpha
motor neurons and motor reflexes. Tizanidine exerts some activity at the postsynaptic
excitatory amino acid receptors and imidazoline receptors which may contribute to
the overall reduction in facilitation of spinal motor neurons. Overall, tizanidine
hydrochloride causes muscle relaxation, reduces spasticity and antinociceptive effects.;
UNII : B53E3NMY5C;
InChIKey : ZWUKMNZJRDGCTQ-UHFFFAOYSA-N;
CAS number : 64461-82-1;
Drug name : Zanaflex;
Chemical formula : C9H8ClN5S.HCl;
Origin ID : C47760;
UMLS CUI : C0771735;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
