NCIt definition : A thioxanthene derivative and a dopamine antagonist with antipsychotic property. Thiothixene
blocks postsynaptic dopamine receptors in the mesolimbic system and medullary chemoreceptor
trigger zone, thereby decreasing dopamine activity leading to decreased stimulation
of the vomiting center and psychotic effects, such as hallucinations and delusions.
In addition, this agent blocks the D2 somatodendritic autoreceptor, thereby increasing
dopamine turnover. Thiothixene possesses weak affinity for the histamine H1 and alpha-adrenergic
receptors.;