Preferred Label : Thimerosal;
NCIt synonyms : Mercury, ethyl(hydrogen o-mercaptobenzoato)-, Sodium Salt(8CI); Merthiolate Sodium; ((o-Carboxyphenyl)thio)ethylmercury, Sodium Salt; Sodium Ethylmercurithiosalicylate; Ethyl(2-mercaptobenzoato-S)mercury, Sodium Salt; Mercurate(1-), Ethyl(2-mercaptobenzoato(2-)-O,S)-, Sodium; Ethylmercurithiosalicylate Sodium;
NCIt definition : An organomercurial compound and derivative of thiosalicyclic acid with antibacterial
and antifungal properties. Although the mechanism of action has not been fully elucidated,
thimerosal inhibits sulfhydryl-containing active site of various enzymes and binds
to sulfhydryl compounds, such as glutathione, cysteine, and SH groups of proteins.
In addition, thimerosal activates the InsP3 calcium channel on endoplasmic reticular
membrane, thereby triggering the release of calcium from intracellular stores resulting
in a calcium-induced calcium-influx of extracellular calcium. Consequently, thimerosal
may induce or inhibit cellular functions dependent on calcium signaling.;
UNII : 2225PI3MOV;
InChIKey : RTKIYNMVFMVABJ-UHFFFAOYSA-L;
CAS number : 54-64-8;
Chemical formula : C9H9HgO2S.Na;
NSC code : 4794;
ChEBI ID : CHEBI:9546;
Origin ID : C47751;
UMLS CUI : C0039867;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
