Preferred Label : Terbutaline Sulfate;
NCIt synonyms : Bricanyl; ( -)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl Alcohol Sulfate(2:1)(salt); 1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol Sulphate; 1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, Sulfate(2:1)(salt);
NCIt definition : The sulfate salt form of terbutaline, an ethanolamine derivative with bronchodilating
and tocolytic properties. Terbutaline sulfate selectively binds to and activates beta-2
adrenergic receptors, leading to intracellular adenyl cyclase activation via a trimeric
G protein and subsequent increase in cyclic cAMP production. Increased cAMP levels
result in relaxation of bronchial and vascular smooth muscle mediated through the
activation of protein kinase A (PKA), which phosphorylates proteins in control of
muscle tone. cAMP also inhibits calcium ion release from intracellular stores, reduces
calcium entry into cells and induces the sequestration of intracellular calcium all
of which aids the relaxation of airway muscles. Terbutaline sulfate also increases
mucociliary clearance and reduces release of inflammatory cell mediators.;
UNII : 576PU70Y8E;
InChIKey : KFVSLSTULZVNPG-UHFFFAOYSA-N;
CAS number : 23031-32-5;
Drug name : Bretine; Brethancer; Brethaire;
Chemical formula : 2C12H19NO3.H2SO4;
ChEBI ID : CHEBI:9450;
Origin ID : C47748;
UMLS CUI : C0039543;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
