Preferred Label : Tadalafil;
NCIt synonyms : (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione;
NCIt related terms : Cialis;
NCIt definition : A carboline-based compound with vasodilatory activity. Tadalafil selectively inhibits
the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated
degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and
corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results
in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus
cavernosa, and, so, prolonged penile erection.;
Alternative definition : NCI-GLOSS: A drug used to treat erectile dysfunction. It is also being studied in
the treatment of sexual problems in patients treated with radiation or surgery for
prostate cancer. Tadalafil blocks the action of a certain enzyme, which can result
in increased blood flow to the penis, causing an erection. It is a type of cGMP phosphodiesterase
type 5 (PDE5) inhibitor.;
UNII : 742SXX0ICT;
InChIKey : WOXKDUGGOYFFRN-IIBYNOLFSA-N;
CAS number : 171596-29-5;
Drug name : Cialis;
Molecule name : Ic351;
Chemical formula : C22H19N3O4;
Codes from synonyms : CDR0000658034; CDR0000658035;
Origin ID : C47743;
UMLS CUI : C1176316;
CISMeF manual mappings
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
