Preferred Label : Sulfisoxazole Acetyl;
NCIt synonyms : Acetamide, N-((4-aminophenyl)sulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)-; N-3,4-Dimethylisoxazol-5-yl-N-sulphanilylacetamide;
NCIt definition : An ester of sulfisoxazole, a broad-spectrum sulfanilamide and a synthetic analog of
para-aminobenzoic acid (PABA) with antibacterial property. Sulfisoxazole acetyl competes
with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the
incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid.
This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis
of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.;
UNII : WBT5QH3KED;
InChIKey : JFNWFXVFBDDWCX-UHFFFAOYSA-N;
CAS number : 80-74-0;
Drug name : Gantrisin;
Chemical formula : C13H15N3O4S;
Origin ID : C47741;
UMLS CUI : C0081437;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
