" /> Sulfinpyrazone - CISMeF





Preferred Label : Sulfinpyrazone;

NCIt synonyms : Enturen; 3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-;

NCIt definition : A phenylbutazone derivative with uricosuric and antithrombotic properties. Sulfinpyrazone competitively inhibits reabsorption of urate at the proximal renal tubule in the kidney. This agent acts on the organic anion transport exchanger, thereby increasing uric acid excretion and decreasing serum uric acid levels resulting in the prevention of urate deposition. Sulfinpyrazone also blocks tubular excretion of various acidic drugs, resulting in increased serum concentration of the drugs. In addition, sulfinpyrazone and its active metabolite inhibit the synthesis of thromboxane A2, by competitively inhibiting the activity of cyclooxygenase, thereby preventing platelet aggregation through restoration of platelet survival time to normal, and decreasing platelet adhesiveness to subendothelial cells.;

UNII : V6OFU47K3W;

InChIKey : MBGGBVCUIVRRBF-UHFFFAOYSA-N;

CAS number : 57-96-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 57-96-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Anturane;

Chemical formula : C23H20N2O3S;

NSC code : 75925;

ChEBI ID : CHEBI:9342;

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16/06/2024


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