Preferred Label : Sulconazole Nitrate;
NCIt synonyms : 1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate,(
-)-; ( -)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate;
NCIt definition : The nitrate salt form of sulconazole, a synthetic imidazole derivative with antifungal
property. Sulconazole nitrate inhibits fungal cytochrome P-450 sterol C-14 alpha-demethylation,
resulting in the accumulation of fungal 14 alpha-methyl sterols and inhibition of
the synthesis of ergosterol, an important component of the fungal cell membrane. Inhibition
of ergosterol synthesis leads to a disruption of cell membrane permeability, and ultimately
inhibition of cell wall synthesis. In addition, sulconazole nitrate seems to interfere
with the autolytic degradation of fungal DNA and RNA.;
UNII : 1T89100D5U;
InChIKey : CRKGMGQUHDNAPB-UHFFFAOYSA-N;
CAS number : 61318-91-0;
Drug name : Exelderm;
Chemical formula : C18H15Cl3N2S.HNO3;
Origin ID : C47733;
UMLS CUI : C0144004;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
