Preferred Label : Sevoflurane;
NCIt synonyms : Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-; 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane;
NCIt definition : A fluorinated isopropyl ether with general anesthetic property. Although the mechanism
of action has not been fully elucidated, sevoflurane may act by interfering with the
release and re-uptake of neurotransmitters at post-synaptic terminals, and/or alter
ionic conductance following receptor activation by a neurotransmitter. Sevoflurane
may also interact directly with lipid matrix of neuronal membranes, thereby affecting
gating properties of ion channels. In addition, this agent may activate gamma-aminobutyric
acid (GABA) receptors hyperpolarizing cell membranes. This results in a general anesthetic
effect, a decrease in myocardial contractility and mean arterial pressure as well
as an increased respiratory rate.;
UNII : 38LVP0K73A;
InChIKey : DFEYYRMXOJXZRJ-UHFFFAOYSA-N;
CAS number : 28523-86-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 28523-86-6
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G-SRS /a ;
Drug name : Ultane;
Chemical formula : C4H3F7O;
ChEBI ID : CHEBI:9130;
Origin ID : C47717;
UMLS CUI : C0074414;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
