NCIt related terms : ChiRhoStim; synthetic human secretin;
NCIt definition : A synthetic human therapeutic agent which is chemically identical or similar to endogenous
secretin, a peptide hormone found in the mucosal S-cells of the proximal small intestine.
Secretin stimulates the pancreatic acinar cells and ductal epithelial cells to emit
bicarbonate rich digestive fluids, thereby increases duodenal bicarbonate level. Bicarbonate
neutralizes acidity of the intestines, consequently increasing the pH and facilitating
the action of intestinal digestive enzymes. In addition, secretin stimulates the stomach
and the liver to produce pepsin and bile, respectively. Both pepsin and bile aide
the digestive action of the duodenum, which resulting in the prevention of gastric
inflammation.;
Alternative definition : NCI-GLOSS: A drug used to help diagnose gastrinomas (tumors that cause too much gastric
acid to be made) and other problems with the pancreas. It is also used to increase
secretions from the pancreas and to help identify a duct called the ampulla of Vater.
Secretin human is a form of secretin that is made in the laboratory. Secretin causes
the pancreas, liver, and stomach to release substances that help digest food.;
UNII : A0426J905J;
CAS number : 108153-74-8;
Drug name : Chirhostim;
Molecule name : RG1068;
Chemical formula : C130H220N44O40;
Codes from synonyms : CDR0000667145; CDR0000667149; CDR0000667147;
Currated CISMeF NLP mapping