" /> Pyridostigmine Bromide - CISMeF





Preferred Label : Pyridostigmine Bromide;

NCIt synonyms : Kalimin; Regonal; Mestinon Bromide; Carbamic Acid,Dimethyl-, Ester with 3-Hydroxy-1-methylpyridinium Bromide; 3-Hydroxy-1-methylpyridinium Bromide Dimethylcarbamate; 3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium Bromide;

NCIt definition : The bromide salt form of pyridostigmine, a quaternary ammonium carbamate derivative and a acetylcholinesterase inhibitor. Pyridostigmine bromide binds reversibly to acetylcholinesterase active sites in the peripheral nervous system, thereby preventing the breakdown of acetylcholine. This leads to an accumulation of acetylcholine at cholinergic synapses and facilitates transmission of impulses across the neuromuscular junction. Mediated through muscarinic receptors, this agent increases contraction of bronchial and intestinal smooth muscle and the exocrine glands secretions, while it causes paralysis of the skeletal muscles mediated through nicotinic receptors. In addition, pyridostigmine is used as a reversible blocking agent to prevent organophosphates from binding to the acetylcholinesterase receptors and thereby protect the nervous system from the effects of nerve agents such as Soman.;

UNII : KVI301NA53;

InChIKey : VNYBTNPBYXSMOO-UHFFFAOYSA-M;

CAS number : 101-26-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 101-26-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Chemical formula : C9H13N2O2.Br;

NSC code : 679759;

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21/05/2024


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