Preferred Label : Pyridostigmine Bromide;
NCIt synonyms : Kalimin; Regonal; Mestinon Bromide; Carbamic Acid,Dimethyl-, Ester with 3-Hydroxy-1-methylpyridinium Bromide; 3-Hydroxy-1-methylpyridinium Bromide Dimethylcarbamate; 3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium Bromide;
NCIt definition : The bromide salt form of pyridostigmine, a quaternary ammonium carbamate derivative
and a acetylcholinesterase inhibitor. Pyridostigmine bromide binds reversibly to acetylcholinesterase
active sites in the peripheral nervous system, thereby preventing the breakdown of
acetylcholine. This leads to an accumulation of acetylcholine at cholinergic synapses
and facilitates transmission of impulses across the neuromuscular junction. Mediated
through muscarinic receptors, this agent increases contraction of bronchial and intestinal
smooth muscle and the exocrine glands secretions, while it causes paralysis of the
skeletal muscles mediated through nicotinic receptors. In addition, pyridostigmine
is used as a reversible blocking agent to prevent organophosphates from binding to
the acetylcholinesterase receptors and thereby protect the nervous system from the
effects of nerve agents such as Soman.;
UNII : KVI301NA53;
InChIKey : VNYBTNPBYXSMOO-UHFFFAOYSA-M;
CAS number : 101-26-8;
Chemical formula : C9H13N2O2.Br;
NSC code : 679759;
Origin ID : C47697;
UMLS CUI : C0034262;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
