" /> Protriptyline Hydrochloride - CISMeF





Preferred Label : Protriptyline Hydrochloride;

NCIt synonyms : Triptil Hydrochloride; Maximed; 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, Hydrochloride;

NCIt definition : The hydrochloride salt form of protriptyline, a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. Protriptyline does not block dopamine transport but may have an indirect dopamine-facilitating effect through interactions of increased peri-synaptic abundance of norepinephrine, particularly in the cerebral cortex, where adrenergic terminals exceed dopaminergic terminals. This results in elevation of mood and behavioral activity. In addition, this agent exhibits anticholinergic activity.;

UNII : 44665V00O8;

InChIKey : OGQDIIKRQRZXJH-UHFFFAOYSA-N;

CAS number : 1225-55-4;

Drug name : Vivactil; Concordin;

Molecule name : MK-240;

Chemical formula : C19H21N.HCl;

NSC code : 169912;

ChEBI ID : CHEBI:8598;

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09/05/2025


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