" /> Propafenone Hydrochloride - CISMeF





Preferred Label : Propafenone Hydrochloride;

NCIt synonyms : Baxarytmon; 1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride; 2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone Hydrochloride;

NCIt definition : The hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias.;

UNII : 33XCH0HOCD;

InChIKey : XWIHRGFIPXWGEF-UHFFFAOYSA-N;

CAS number : 34183-22-7;

Drug name : Rythmol;

Chemical formula : C21H27NO3.HCl;

NSC code : 37855;

ChEBI ID : CHEBI:8466;

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31/05/2025


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