" /> Proguanil Hydrochloride - CISMeF





Preferred Label : Proguanil Hydrochloride;

NCIt synonyms : 1-(p-Chlorophenyl)-5-isopropylbiguanide Hydrochloride; Chloroquanil; Bigumalum; Imidodicarbonimidic Diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Monohydrochloride(9CI); Chloroguanide Hydrochloride;

NCIt definition : The hydrochloride salt form of proguanil, a synthetic biguanide derivative of pyrimidine and an folate antagonist with antimalarial property. Upon hydrolysis, proguanil is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.;

UNII : R71Y86M0WT;

InChIKey : SARMGXPVOFNNNG-UHFFFAOYSA-N;

CAS number : 637-32-1;

Drug name : Chloriguane; Chlorguanide;

Chemical formula : C11H16ClN5.HCl;

NSC code : 26614; 12977;

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08/05/2025


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