NCIt definition : The hydrochloride salt form of procyclidine, with anticholinergic properties. Procyclidine
hydrochloride competitively binds to striatal cholinergic receptors, thereby diminishing
acetylcholine activity and ultimately reducing the frequency and severity of akinesia,
rigidity, and tremor associated with uncontrollable body movements. In addition, this
agent may block the re-uptake of dopamine by nerve terminals, thereby increasing dopamine
activity.;