Preferred Label : Procainamide Hydrochloride;
NCIt synonyms : Novocamid Hydrochloride; Pronestyl-SR; Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, Monohydrochloride;
NCIt definition : The hydrochloride salt form of procainamide, an amide derivative exhibiting class
1A antiarrhythmic property and analog of procaine. Procainamide hydrochloride reversibly
binds to and blocks activated (open) voltage-gated sodium channels, thereby blocks
the influx of sodium ions into the cell, which leads to an increase in threshold for
excitation and inhibit depolarization during phase 0 of the action potential. In addition,
the effective refractory period (ERP), action potential duration (APD), and ERP/APD
ratios are increased, resulting in decreased impulse conduction velocity. The lasting
action potential may also be due to blockage of outward K currents. The result is
a decrease in automaticity, increase in refractory period and slowing of impulse conduction.;
UNII : SI4064O0LX;
InChIKey : ABTXGJFUQRCPNH-UHFFFAOYSA-N;
CAS number : 614-39-1;
Drug name : Procan SR; Pronestyl; Promine;
Chemical formula : C13H21N3O.HCl;
NSC code : 27461;
ChEBI ID : CHEBI:8429;
Origin ID : C47687;
UMLS CUI : C0600311;
Semantic type(s)
- Validated automatic mappings to NTBT
- concept_is_in_subset
- has_free_acid_or_base_form
- is_salt_form_of
