Preferred Label : Primidone;
NCIt synonyms : Neurosyn; 2-Deoxyphenobarbital; Primaclone; Mysedon; 4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-;
NCIt definition : An analog of phenobarbital with antiepileptic property. Although the mechanism of
action has not been fully elucidated, primidone probably exerts its actions, in a
manner similar to phenobarbital, via activation of gamma-aminobutyric acid (GABA)-A
receptor/chloride ionophore complex, which leads to prolonged and increased frequency
of opening of the chloride channel within the receptor complex. This results in an
alteration in the electrical activity of the nerve cell membrane, causing hyperpolarization
and prevention of partial and tonic-clonic seizures. In addition, this agent is partially
metabolized to phenobarbital and phenylethylmalonamide (PEMA), which may also contribute
to its anti-seizure properties.;
UNII : 13AFD7670Q;
InChIKey : DQMZLTXERSFNPB-UHFFFAOYSA-N;
CAS number : 125-33-7;
Drug name : Mysoline, Apo-Primidone; Myidone;
Chemical formula : C12H14N2O2;
NSC code : 41701;
ChEBI ID : CHEBI:8412;
Origin ID : C47686;
UMLS CUI : C0033148;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
