Praziquantel - CISMeF

Preferred Label : Praziquantel;

NCIt synonyms : Droncit; 4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-;

NCIt definition : A pyrazinoisoquinoline derivative with anthelminthic property. Praziquantel increases the permeability of the tegument of susceptible worms, resulting in an influx and increase in intra-tegumental calcium leading to rapid contractions and paralysis of the worm's musculature through a subsequent increase in levels of calcium in the sarcoplasmic reticulum. In addition, vacuolization of the tegumental syncytium and blebbing results in tegument disintegration, leads to antigen exposure and elicit host defense responses to the worm. The result is the formation of granulomas and phagocytosis.;

UNII : 6490C9U457;

InChIKey : FSVJFNAIGNNGKK-UHFFFAOYSA-N;

CAS number : 55268-74-1;

Drug name : Biltricide;

Chemical formula : C19H24N2O2;

ChEBI ID : CHEBI:45267;

Codes from synonyms : 582;

Details

Origin ID

C47683;

UMLS CUI

C0032911;

See also inter- (CISMeF)
- Product containing praziquantel (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Praziquantel [ICD-11 Extension code]
- Praziquantel (substance) [SNOMED CT concept]
- Product containing praziquantel (medicinal product) [SNOMED CT concept]
- praziquantel [ATC Code]
- praziquantel [Substance BNPC]
- praziquantel [MeSH Descriptor]
- praziquantel [MeSH concept]
- praziquantel [SNOMED Notion]
Validated automatic mappings to BTNT
- praziquantel [ATC Code]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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